2025 March Madness Final Four Odds: Duke, Florida Lead as Regional Favorites
The 2025 NCAA Tournament bracket features odds for all 68 teams to reach the Final Four, with #1 seeds emerging as favorites in each region.
Player cuts championship basketball net
East Region
- Duke (-115): Top favorite with Cooper Flagg returning from injury
- Alabama (+475)
- Wisconsin (+900)
- Arizona (+950)
Duke leads all metrics, including KenPom ratings at +38.16, two points ahead of second-ranked Florida.
Midwest Region
- Houston (+155): Dominated Big 12 with 19-1 record
- Tennessee (+340)
- Gonzaga, Kentucky, Illinois (all tied at +850)
Gonzaga enters with nine consecutive Sweet 16 appearances, the longest active streak nationwide.
South Region
- Auburn (+110)
- Michigan State (+470)
- Iowa State (+850)
- Texas A&M (+1200)
Notable: #11 North Carolina (+4500) shows stronger odds than higher-seeded teams despite First Four status.
West Region
- Florida (-110): Secured final #1 seed after dominant SEC Tournament
- Texas Tech (+470)
- St John's (+600)
Unique case: #12 Colorado State (+6500) favored over #5 Memphis (+9000) in first-round matchup.
These odds reflect opening lines and may fluctuate as the tournament progresses. Duke remains the overall tournament favorite at +350 to win the championship.