
Gonzaga vs Houston NCAA Betting Lines: Cougars Open as 4.5-Point Favorites
#8 Gonzaga and #1 Houston face off in a highly anticipated second-round March Madness matchup after both teams dominated their first-round opponents. The game will take place at INTRUST Bank Arena in Wichita, KS.

White-uniformed player shooting basketball
Opening Odds:
- Spread: Houston -4.5
- Moneyline: Houston -196 / Gonzaga +162
- Over/Under: 139.5
- Implied Win Probability: Houston 65.75% / Gonzaga 38.17%
Key Team Statistics:
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Houston (31-4, 19-16 ATS)
- 14-game win streak
- #3 in KenPom Net Rating
- Last loss: Feb. 1 vs Texas Tech
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Gonzaga (26-8, 15-19 ATS)
- #9 in KenPom Net Rating
- Shot 60% from three in first round
- Led by Ryan Nembhard (10.8 PPG, 9.8 APG)
First Round Performance:
- Houston defeated SIU Edwardsville 78-40
- Gonzaga beat Georgia 89-68
Notable Factors:
- First-ever meeting between the schools
- Common opponents: Both teams beat Baylor
- Gonzaga beat San Diego State (80-67), who defeated Houston (73-70 OT)
- Houston's defense ranks among nation's best
- Gonzaga's offensive efficiency is their strength
The narrow spread reflects the analytics showing these teams are closer in skill than their seeding suggests, despite Houston's superior regular season record against tougher competition.
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