Opening odds for the 2025 NCAA Tournament first-round games reveal several notable betting lines and trends. Here are the key highlights and analysis:

Notable First-Round Lines:

• #12 Colorado State (-3.5) favored over #5 Memphis
• Largest spread: Houston (-27.5) vs SIU Edwardsville
• Second-largest: Florida (-26.5) vs Norfolk State

Key Totals to Watch:

Highest Total:

• Akron vs Arizona (167.5)
• Both teams play up-tempo (Arizona 54th, Akron 16th fastest)
• Akron is 19-12-1 O/U (61.3% over rate)

Lowest Total:

• SIU Edwardsville vs Houston (127.5)
• Houston: #1 rated defense, 5th-slowest pace
• KenPom projects: Houston 75, SIUE 51

Tournament Updates:

• Cooper Flagg cleared to play, Duke returns as outright favorite
• Colorado State line moved from -2.5 to -3.5 vs Memphis due to analytics ratings
• Florida enters on strong momentum after SEC Tournament title

Key Stats:

• Arizona: 19-15 over/under
• Houston: 14-19-1 over/under
• SIUE: 15-16 over/under

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