Louisville vs Creighton March Madness First Round: Predictions and How to Watch 8 vs 9 Matchup

Louisville vs Creighton March Madness First Round: Predictions and How to Watch 8 vs 9 Matchup

By Michael Harrison

March 24, 2025 at 12:02 AM

The #8 Louisville Cardinals (27-7) face the #9 Creighton Bluejays (24-10) in a compelling March Madness first-round matchup. Louisville enters as 2.5-point favorites after winning 21 of their last 23 games.

Basketball player wearing black jersey

Basketball player wearing black jersey

Game Details:

  • Time: 12:15pm ET
  • Location: Rupp Arena, Lexington, KY
  • TV: CBS
  • Spread: Louisville -2.5 (-110)
  • Moneyline: Louisville -155, Creighton +130
  • Total: 145.5

Key Factors:

  • Louisville has home-court advantage playing in Kentucky
  • Cardinals finished 18-2 in ACC regular season
  • Louisville ranks 23rd in KenPom (Creighton 36th)
  • Cardinals' strong guard play led by Chucky Hepburn (16 PPG, 6 APG)
  • Louisville's perimeter defense holds opponents under 34% from 3

Why Louisville Will Win:

  • Elite backcourt featuring ACC Defensive Player of the Year Hepburn
  • Four senior starters provide crucial experience
  • Strong perimeter defense to contain Creighton's shooters
  • Effective double-team strategy against opposing big men
  • Home court advantage in Kentucky

Creighton Concerns:

  • Lost second-leading scorer Pop Isaacs earlier this season
  • Steven Ashworth's 22% turnover rate vulnerable against pressure
  • Three-point shooting ranks 178th nationally (34% of attempts)
  • Heavily reliant on center Ryan Kalkbrenner

Prediction: Louisville's superior guard play, home-court advantage, and defensive prowess should lead them to victory. The Cardinals match up well with Creighton's size and can effectively neutralize Kalkbrenner with double teams. Take Louisville -2.5.

Looking ahead, Louisville could be a dark horse Final Four contender if they can upset top-seeded Auburn in a potential second-round matchup.

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