Sweet 16 Odds 2025: Duke, Florida Lead All 68 Tournament Teams' Chances
The 2025 NCAA Tournament features 68 teams vying for March Madness glory. Here's a comprehensive breakdown of Sweet 16 odds and best betting picks.
Gators celebrate on basketball court
Top Favorites (Odds from BetMGM)
Duke (-650) and Florida (-650) lead the pack as co-favorites to reach the Sweet 16. Duke's freshman sensation Cooper Flagg (19.1 PPG, 8.3 RPG, 3.9 APG) powers their dominant ACC campaign, while Florida boasts the nation's most efficient offense behind Walter Clayton Jr. and Will Richard.
Houston (-300) and Auburn (-400) round out the #1 seeds with strong odds. Houston's elite defense and Auburn's Johni Broome make them serious contenders.
Value Picks
Tennessee (-275) and St. John's (-150) stand out among #2 seeds. Tennessee's third-ranked defense and experienced backcourt of Zakai Zeigler and Chaz Lanier (40.5% from three) provide excellent value. St. John's leads the nation in defensive efficiency under Rick Pitino.
Best Longshot Picks
- Grand Canyon (+1400): Coach Bryce Drew's squad has upset potential
- Yale (+900): Disciplined style led by Bez Mbeng
- Colorado State (+350): Hot team after Mountain West title
- Gonzaga (+250): Elite offense with NBA prospect Seamus Boone
CBS Sports Game Highlights
Teams to Avoid
- Kentucky (+110): Too inconsistent despite talent
- Kansas (+190): Defensive concerns
- Wisconsin (-115): Overvalued #3 seed
- UConn (+600): Bottom-90 defensive efficiency
- Iowa State (-175): Recent injury concerns
Basketball players jumping for ball
Best Strategy: Mix safe favorites with calculated value plays and select longshots. Consider team matchups, recent form, and defensive metrics when making selections.
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