NFL Draft 2025: Top-5 Pick Odds & Expert Betting Predictions

By Michael Harrison

May 1, 2025 at 09:49 AM

The Tennessee Titans hold the first overall pick in the 2025 NFL Draft, with Miami quarterback Cam Ward expected as their selection. Let's analyze the top betting odds and valuable picks for the draft's first five selections.

Quarterback throws football in game

Quarterback throws football in game

Top-5 Pick Odds Leaders:

  • Will Campbell (OT): -475 (82.6% implied probability)
  • Ashton Jeanty (RB): -220 (68.8% implied probability)

Value Pick: Ashton Jeanty (-220)

  • Nation's leading rusher with 2,601 yards in 14 games
  • 29 touchdowns and 7.0 yards per carry average
  • Second in Heisman Trophy voting
  • Jacksonville native with Jaguars picking fifth
  • Could be first RB taken in top-5 since Saquon Barkley (2018)

Sleeper Pick: Shedeur Sanders (+500)

  • Strong final college season: 4,134 yards, 37 TDs, 10 INTs
  • Led Colorado to 9-4 record
  • Potential fit for Browns (2nd pick) or Giants (3rd pick)
  • Mixed pre-draft evaluations could be smokescreens
  • Name recognition and lineage could influence selection

Key Draft Considerations:

  • Cleveland Browns need QB replacement for Deshaun Watson
  • Giants selecting third overall could target Sanders
  • Travis Hunter (CB/WR) competing for early selection
  • Draft positioning trades could affect final order

The NFL Draft market has become increasingly sophisticated, making value bets harder to find. However, both Jeanty and Sanders present interesting opportunities at their current odds, with team needs and draft-day trades potentially reshaping the top-5 landscape.

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