The Week 13 Sunday Night Football matchup features the Indianapolis Colts visiting the Dallas Cowboys at AT&T Stadium. The Cowboys enter as 10.5-point favorites in this inter-conference clash between second-place teams.

The Colts are coming off a close Monday night loss to the Steelers, where their run defense struggled. Their biggest challenge will be protecting quarterback Matt Ryan against Dallas's league-leading pass rush. The Colts will need creative protection schemes using extra blockers to give Ryan time in the pocket.

The Cowboys are riding momentum after their Thanksgiving win over the Giants, where their defense contained Saquon Barkley effectively. Their offense has hit its stride since Dak Prescott's return, with the Prescott-CeeDee Lamb connection flourishing and Michael Gallup emerging as another weapon.

Key Factors:

• Colts must establish the run game to reduce pressure on Matt Ryan
• Cowboys' pass rush vs Colts' offensive line will be crucial
• Dallas needs disciplined defense despite being heavy favorites
• Colts must disguise run plays effectively

Game Essentials:

• Location: AT&T Stadium, Arlington
• Spread: Cowboys -10.5
• Teams' Status: Both second place in respective divisions
• Key Matchup: Cowboys' pass rush vs Colts' pass protection

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