NFL Thanksgiving Day 2021: Expert Moneyline Predictions and Analysis

NFL Thanksgiving Day 2021: Expert Moneyline Predictions and Analysis

By Michael Harrison

March 19, 2025 at 07:29 PM

Here's your concise NFL Thanksgiving betting guide with moneyline picks for all three games:

Bears @ Lions (12:30 PM ET, FOX)

  • Bears missing Justin Fields; Lions seeking first win
  • Detroit showing fight lately with tie vs Pittsburgh and close loss to Browns
  • Lions favored despite winless record
  • Pick: Lions ML (+135)

Raiders @ Cowboys (4:30 PM ET, CBS)

  • Cowboys looking to bounce back after KC loss
  • Raiders on 2-game skid, lacking weapons without Ruggs
  • Dallas the superior team despite recent struggles
  • Pick: Cowboys ML (-335)

Bills @ Saints (8:20 PM ET, NBC)

  • Bills struggling with run game and inconsistent offense
  • Saints limited offensively beyond Kamara
  • Buffalo should win but spread (6.5) too wide
  • Pick: Bills ML (-278)

Parlay Option: Lions + Cowboys + Bills ML parlay pays +315

Key Factors:

  • Lions showing improvement despite record
  • Cowboys have offensive firepower advantage
  • Bills' defense should contain limited Saints offense

Note: Always bet responsibly. Odds subject to change.

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