The Indianapolis Colts (-2.5) host the Pittsburgh Steelers on Monday Night Football in Week 12, with both AFC teams looking to improve their struggling records.

The Steelers (3-7) aim to secure just their second road win of the season. Their success hinges on:

• Stopping the Colts' run-focused offense
• Getting Najee Harris (550 yards, 27th in NFL) going after back-to-back 90+ yard games
• Forcing Matt Ryan to beat them through the air

The Colts (4-6-1) look to bounce back after a close loss to Philadelphia. Keys for Indianapolis:

• Maintaining Matt Ryan's efficiency (70%+ completion rate since returning as starter)
• Diversifying the run game with play-action and misdirection
• Improving on Ryan's modest 217.5 passing yards per game average

Both teams have historically been AFC powerhouses but are struggling in 2022. The winner will be determined by offensive execution, with the Colts entering as slight home favorites.

The run game will be crucial - Pittsburgh needs another strong performance from Harris, while Indianapolis must establish their ground attack without becoming predictable. Creative play-calling and mixing in play-action passes will be essential for the Colts' success at home.

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