Here's your comprehensive MLB Opening Day betting guide for April 7, 2022, with key matchups and betting recommendations:

Milwaukee Brewers at Chicago Cubs (2:21 p.m. ET)

• Spread: Milwaukee -1.5
• Total: 10 runs
• Pitching: Corbin Burnes (11-5, 2.43 ERA) vs Kyle Hendricks (14-7, 4.77 ERA)
• Recommendation: Brewers to win and cover, Under 10 runs

Cleveland Guardians at Kansas City Royals (4:11 p.m. ET)

• Spread: Cleveland -1.5
• Total: 8 runs
• Pitching: Shane Bieber vs Zack Greinke
• Recommendation: Royals +1.5, Under 8 runs

Pittsburgh Pirates at St. Louis Cardinals (4:16 p.m. ET)

• Spread: St. Louis -1.5
• Total: 8 runs
• Pitching: Adam Wainwright vs TBD
• Recommendation: Cardinals to win and cover, Under 8 runs

New York Mets at Washington Nationals (7:06 p.m. ET)

• Spread: New York -1.5
• Total: 9 runs
• Pitching: Tylor Megill (4-6, 4.52 ERA) vs Patrick Corbin (9-16, 5.82 ERA)
• Recommendation: Mets to win and cover, Over 9 runs

Cincinnati Reds at Atlanta Braves (8:09 p.m. ET)

• Spread: Atlanta -1.5
• Total: 8 runs
• Pitching: Max Fried (14-7, 3.04 ERA) vs Tyler Mahle (13-6, 3.75 ERA)
• Recommendation: Braves to win and cover, Under 8 runs

Houston Astros at Los Angeles Angels (9:39 p.m. ET)

• Spread: Los Angeles -1.5
• Total: 8.5 runs
• Pitching: Framber Valdez (11-4, 3.14 ERA) vs Shohei Ohtani (9-2, 3.18 ERA)
• Recommendation: Houston +1.5, Over 8.5 runs

San Diego Padres at Arizona Diamondbacks (9:41 p.m. ET)

• Spread: San Diego -1.5
• Total: 9 runs
• Pitching: Yu Darvish (8-11, 4.22 ERA) vs Madison Bumgarner (7-10, 4.67 ERA)
• Recommendation: Padres to win and cover, Under 9 runs

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