March Madness Round of 64: Day Two Betting Guide and Predictions

March Madness Round of 64: Day Two Betting Guide and Predictions

By Michael Harrison

March 15, 2025 at 07:19 AM

Currently riding a 9-5 hot streak in March Madness picks, here's a comprehensive betting preview for Day Two of the Round of 64:

#7 Ohio State (+0.5) vs #10 Loyola Chicago

  • 66% of public money on Loyola Chicago
  • OSU advantages:
    • Healthy roster with Key and Young returning
    • Superior offense vs Loyola's defense
    • Pittsburgh location provides home court advantage
  • Pick: Ohio State +0.5

#6 Texas (-1) vs #11 Virginia Tech

  • Texas strengths:
    • Elite defense per KenPom metrics
    • Chris Beard's difficult "no middle" defensive scheme
    • Solid offensive efficiency
  • Virginia Tech concerns:
    • Inflated offensive numbers from weak ACC
    • Hot streak may not be sustainable
  • Pick: Texas -1

#7 Michigan State vs #10 Davidson (O/U 140)

  • Key factors:
    • MSU's strong defense should contain Davidson
    • Spartans struggling offensively lately
    • Davidson held to 62 points in A10 Championship
  • Pick: Under 140

#6 LSU vs #11 Iowa State (+4)

  • Analysis:
    • LSU head coach firing hurts team chemistry
    • Iowa State's Brockington is a game-changer
    • Both teams have top-10 defenses
    • Coaching change may impact LSU's defense
  • Picks: Iowa State +4, Over 126, Iowa State ML (+160) 0.5u

Betting record: 9-5 since tournament started. Always bet responsibly.

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