The NCAA Tournament's South Region heads into the Sweet 16 with three top-five seeds still in contention, alongside the surprising Michigan Wolverines. Here's a comprehensive breakdown of the matchups and predictions:

Villanova (-5.0) vs. Michigan

• Villanova's efficient offense faces Michigan's interior-focused scoring
• Both teams excel defensively
• Key factor: Offensive execution will determine the outcome
• Prediction: Villanova to win and cover the 5-point spread

Arizona (-1.5) vs. Houston

• Contrasting styles: Arizona's high-scoring offense vs. Houston's strong defense
• Arizona averages 80 points per game
• Arizona holds advantages in athleticism
• Prediction: Arizona to win and cover the slim 1.5-point spread

Regional Final Prediction

• Projected matchup: Arizona vs. Villanova
• Arizona's explosive offense expected to overwhelm Villanova
• Prediction: Arizona advances to Final Four

The South Region's top seed Arizona looks poised to emerge victorious, leveraging their dynamic offensive capabilities to overcome both Houston in the Sweet 16 and potentially Villanova in the Elite Eight.

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