Guardians vs White Sox: AL Central Rivals Clash in Key July 22 Matchup

By Michael Harrison

May 29, 2025 at 02:15 PM

The Cleveland Guardians (46-44) face the Chicago White Sox (46-46) at Guaranteed Rate Field on July 22 at 8:10 p.m. in a crucial AL Central matchup. Both teams are within striking distance of the division-leading Minnesota Twins, with Cleveland just 2 games back and Chicago 3 games behind.

Game Details:

  • White Sox are favored at -158
  • Guardians moneyline: +134
  • Run line: Cleveland +1.5 (-162)
  • Over/Under: 8.5 runs

Pitching Matchup:

  • Guardians: Cal Quantrill (6-5, 3.75 ERA, 1.29 WHIP)
  • White Sox: Lucas Giolito (6-5, 4.69 ERA, 1.40 WHIP)

Key Players: Guardians:

  • José Ramírez: .288/.368/.576, 19 HR, 75 RBI, 13 SB
  • Josh Naylor: .274 AVG, 13 HR, 47 RBI
  • Andrés Giménez: .296 AVG, 10 HR, 43 RBI

White Sox:

  • Luis Robert: .301/.334/.461, 12 HR, 54 RBI, 11 SB
  • José Abreu: .304/.387/.470, 11 HR, 46 RBI, 52 runs

Recent Form:

  • Guardians: 5-2 in last 7 games, 6-3 vs White Sox
  • White Sox: Won 3 of 4 against Twins before break
  • Cleveland struggling on road (1-7 in last 8)

This pivotal divisional matchup will likely come down to pitching performance, with both starters showing inconsistency this season. Cleveland's recent success against Chicago (6-3) gives them an edge despite being road underdogs.

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