The #5 ranked Ohio State Buckeyes (5-1) face the Indiana Hoosiers (2-4) on Saturday at 7:30 p.m. EST. Ohio State enters as heavy 21-point road favorites after winning their last three games by 20+ points.

Key Betting Information:

• Spread: Ohio State -21 (-110)
• Over/Under: 59.5 (-110)
• Ohio State has hit the over in 9 of last 12 games
• Indiana is 1-6 ATS in last 7 games
• Indiana has hit the under in last 5 Big Ten games

Ohio State's Path to Victory:

• Nation's #1 offense in yards and points per game
• Defense showing improvement after early struggles
• Dominant wins since Oregon loss
• Fighting for College Football Playoff spot

Indiana's Keys to Upset:

• QB Michael Penix Jr. must improve (54% completion, 4 TD, 7 INT)
• Defense ranks 33rd in yards allowed
• Need turnovers and pressure to slow OSU offense
• Must protect home field advantage

Prediction: Ohio State's superior talent and playoff aspirations should lead to a comfortable road win. Expect the Buckeyes to cover the spread, though it may take time to pull away. Their explosive offense and improved defense will be too much for a struggling Indiana team to handle.

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