Best MLB Three-Team Parlay Picks for September 22: Brewers, Yankees, Guardians

Best MLB Three-Team Parlay Picks for September 22: Brewers, Yankees, Guardians

By Michael Harrison

March 17, 2025 at 05:41 PM

Here's a concise, value-focused version of the MLB parlay article for September 22:

Looking for a winning MLB parlay? Here's a three-team combination with strong potential for Thursday's loaded slate:

Milwaukee Brewers (-150) vs. Cincinnati Reds

  • Brandon Woodruff (11-4, 3.26 ERA) starts for Brewers
  • Brewers fighting for Wild Card spot, 2.5 games back
  • Facing struggling Hunter Greene (4-12) and last-place Reds
  • Early scoring advantage expected for Milwaukee

New York Yankees (-170) vs. Boston Red Sox

  • Yankees coming off 14-2 win against Pirates
  • Aaron Judge at 60 home runs for the season
  • Yankees have 97 more home runs than Red Sox in 2022
  • Clear offensive advantage favors Yankees at home

Cleveland Guardians (-135) vs. Chicago White Sox

  • Shane Bieber (11-8) starting for Cleveland
  • Bieber ranks top 15 in ERA, strikeouts, and WHIP
  • Guardians lead season series 11-7
  • Cleveland looking to extend 6-game AL Central lead

This parlay targets three teams with strong pitching matchups and playoff implications. The Brewers need wins for Wild Card contention, the Yankees are riding offensive momentum, and the Guardians aim to secure their division title.

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