The Green Bay Packers (-5.5) host the San Francisco 49ers in a crucial Week 12 NFC matchup. The betting lines shifted dramatically after 49ers quarterback Brock Purdy (shoulder) and EDGE Nick Bosa (hip/oblique) were ruled out.

The total has dropped from 48.5 to 44.5, with 74% of bets favoring the Under. Kickoff is set for 4:25 pm ET at Lambeau Field on FOX.

Brandon Allen will start for San Francisco, making just his 10th career start since 2016. The journeyman quarterback hasn't started since 2021 and holds a 2-7 career record as starter. The 49ers will likely lean heavily on Christian McCaffrey and the league's 8th-ranked rushing attack.

The Packers (7-3) look to capitalize on San Francisco's injuries. Quarterback Jordan Love continues to show both promise and inconsistency, leading the league with 11 interceptions while displaying playmaking ability. Green Bay's fourth-ranked rushing attack, led by Josh Jacobs, should feature prominently.

Key Factors:

• 49ers have lost three games when leading in the final two minutes
• Last three meetings decided by three points or less
• 49ers defense remains strong despite Bosa's absence
• Trent Williams (ankle) questionable for San Francisco
• Green Bay coming off narrow win against Chicago

The 49ers (5-5) remain just one game out of first place in the NFC West despite recent struggles. While Purdy's absence is significant, coach Kyle Shanahan's offensive scheme and McCaffrey's presence should keep this game competitive.

Prediction: 49ers +5.5 (-110)

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